Myxoedema Coma
Myxoedema coma is an extreme manifestation of untreated hypothyroidism and is a life-threatening condition characterised by hypometabolism and altered mental status. It commonly affects elderly patients with long-standing hypothyroidism, often precipitated by...
Levels of Evidence and Grading Systems
Levels of evidence A hierarchical system of classifying evidence is an essential part of evidence-based medicine. This hierarchy is commonly referred to as the levels of evidence. When attempting to find the answer to a clinical conundrum, a clinician should actively...
Togo and the Diphtheria Serum Run
Thanks to modern childhood vaccination programs, diphtheria is now a rare illness in Western Europe and the United States. It is still common, however, in developing countries where vaccination rates are low. It is a terrifying illness caused by the airborne bacterium...
Addisonian Crisis
An Addisonian crisis, also known as an adrenal crisis, is a severe and potentially life-threatening condition that arises due to acute adrenal insufficiency. It is a rare condition with an estimated prevalence of around 600 per million, but it does present to the...
