Myxoedema Coma

Myxoedema Coma

Myxoedema coma is an extreme manifestation of untreated hypothyroidism and is a life-threatening condition characterised by hypometabolism and altered mental status. It commonly affects elderly patients with long-standing hypothyroidism, often precipitated by...
Levels of Evidence and Grading Systems

Levels of Evidence and Grading Systems

Levels of evidence A hierarchical system of classifying evidence is an essential part of evidence-based medicine. This hierarchy is commonly referred to as the levels of evidence. When attempting to find the answer to a clinical conundrum, a clinician should actively...
Togo and the Diphtheria Serum Run

Togo and the Diphtheria Serum Run

Thanks to modern childhood vaccination programs, diphtheria is now a rare illness in Western Europe and the United States. It is still common, however, in developing countries where vaccination rates are low. It is a terrifying illness caused by the airborne bacterium...
Addisonian Crisis

Addisonian Crisis

An Addisonian crisis, also known as an adrenal crisis, is a severe and potentially life-threatening condition that arises due to acute adrenal insufficiency. It is a rare condition with an estimated prevalence of around 600 per million, but it does present to the...
Cardiac Arrest in Pregnancy: Critical Considerations 

Cardiac Arrest in Pregnancy: Critical Considerations 

The management of cardiac arrest during pregnancy presents unique challenges that demand specialised knowledge and swift action. Maternal cardiac arrest is a rare but high-stakes scenario that requires a comprehensive understanding of resuscitation techniques tailored...
Thyroid Storm

Thyroid Storm

Thyroid storm, also known as thyrotoxic crisis, is a rare but life-threatening condition characterised by an extreme exacerbation of thyrotoxicosis symptoms. It occurs in approximately 1-2% of patients with established hyperthyroidism. This medical emergency demands...