Cytochrome p450 Enzymes and Drug Metabolism

Cytochrome p450 Enzymes and Drug Metabolism

Many drugs are metabolised in the liver. Drugs are either metabolised by phase I reactions (oxidation, reduction, or hydrolysis) or phase II reactions (e.g. glucuronidation). Phase I reactions are mainly carried out by the cytochrome P450 family of isoenzymes, of...
Building a Career in Global Health and Expedition Medicine

Building a Career in Global Health and Expedition Medicine

Building a career in global health and expedition medicine – the good, the bad, and the stuff no one tells you! Can I be a neurosurgeon and travel the world with my work? I’d like to do paediatrics but with some humanitarian work- is that possible? Will I still...
Pertussis

Pertussis

Pertussis, also known as whooping cough, is an upper respiratory tract infection caused by the Gram-negative bacteria Bordatella pertussis. Transmission is via respiratory droplets and the incubation period is approximately 7-21 days. The disease is highly contagious...
Understanding Homeostasis

Understanding Homeostasis

Homeostasis is the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant. Examples of homeostasis include the regulation of temperature and pH balance. The two body systems that are responsible for...
HELLP Syndrome

HELLP Syndrome

HELLP syndrome is a pregnancy complication that usually presents in women who have pre-eclampsia or eclampsia. Affected women also show signs of liver damage and abnormalities in blood clotting. HELLP syndrome is characterised by: Haemolysis ELevated liver enzymes Low...
What is Evidence-based Medicine?

What is Evidence-based Medicine?

Evidence-based medicine is the term used to describe the process of systematically reviewing, appraising and using the findings of clinical research to assist with the delivery of optimum clinical care to patients. The most commonly quoted definition of evidence-based...